Phenotypes Associated with This Genotype

Genotype
MGI:4420956

• Allelic Composition: Ncdn^tm1.1Mfla/Ncdn^tm1.1Mfla; Tg(Camk2a-cre)2Gsc/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to xenobiotic ( J:155805 )

• increased locomotion in response to MK-801, an NMDA antagonist

induced hyperactivity ( J:155805 )

• in response to MK-801, an NMDA antagonist

• however, no difference in baseline activity levels is detected

nervous system

reduced long-term potentiation ( J:155805 )

• the induction of LTP in the Schaffer collateral to CA1 synapses is abolished

decreased prepulse inhibition ( J:155805 )

• compared with wild-type littermate controls, show impaired PPI at a prepulse intensity of 74 dB

• however, the baseline startle response is not different from controls

reduced long-term depression ( J:155805 )

• show reduced (RS)-3,5-dihydroxyphenylglycine induced long term depression