Phenotypes Associated with This Genotype

Genotype
MGI:4420927

• Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj; Fah^tm1Mgo/Fah^tm1Mgo
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:138701 )

N • mice survive NTBC withdrawal unlike similarly treated Fah^tm1Mgo homozygotes

neoplasm

increased hepatocellular carcinoma incidence ( J:138701 )

• 7 to 8 weeks following NTBC withdrawal and 8 weeks following low-dose NTBC treatment, mice develop hepatocellular carcinomas unlike similarly treated Fah^tm1Mgo homozygotes

• tumors that develop following treatment with low-dose NTBC are smaller and fewer than those in mice following complete withdrawal of NTBC

increased renal carcinoma incidence ( J:138701 )

• in 80% of mice 12 weeks after NTBC withdrawal

liver/biliary system

abnormal hepatocyte morphology ( J:138701 )

• following NTBC withdrawal, hepactocytes are dysplastic with increased DNA damage compared with cells from similarly treated Fah^tm1Mgo homozygotes

increased hepatocellular carcinoma incidence ( J:138701 )

• 7 to 8 weeks following NTBC withdrawal and 8 weeks following low-dose NTBC treatment, mice develop hepatocellular carcinomas unlike similarly treated Fah^tm1Mgo homozygotes

• tumors that develop following treatment with low-dose NTBC are smaller and fewer than those in mice following complete withdrawal of NTBC

abnormal liver physiology ( J:138701 )

• following NTBC withdrawal, hepatocytes exhibit increased DNA damage compared with similarly treated cells from Fah^tm1Mgo homozygotes

increased hepatocyte apoptosis ( J:138701 )

• following NTBC withdrawal

increased hepatocyte proliferation ( J:138701 )

• following NTBC withdrawal unlike in similarly treated Fah^tm1Mgo homozygotes

renal/urinary system

kidney cyst ( J:138701 )

• 10 weeks after NTBC withdrawal, mice develop macroscopic cysts comprised of renal parenchyma unlike similarly treated Fah^tm1Mgo homozygotes

increased renal carcinoma incidence ( J:138701 )

• in 80% of mice 12 weeks after NTBC withdrawal

dilated proximal convoluted tubule ( J:138701 )

• following NTBC withdrawal

growth/size/body

weight loss ( J:138701 )

• following NTBC withdrawal, mice exhibit weight loss with a plateau at 5 and 6 weeks after withdrawal compared with similarly treated Fah^tm1Mgo homozygotes

kidney cyst ( J:138701 )

• 10 weeks after NTBC withdrawal, mice develop macroscopic cysts comprised of renal parenchyma unlike similarly treated Fah^tm1Mgo homozygotes

cellular

increased hepatocyte apoptosis ( J:138701 )

• following NTBC withdrawal

increased hepatocyte proliferation ( J:138701 )

• following NTBC withdrawal unlike in similarly treated Fah^tm1Mgo homozygotes