Phenotypes Associated with This Genotype

Genotype
MGI:4420906

• Allelic Composition: Itga2^tm1.1Eck/Itga2⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal platelet physiology ( J:75683 )

• expression levels of integrin beta1 are decreased by ~15% whereas expression of alpha5 and alpha6 is significantly increased in heterozygous mutant platelets relative to control platelets

decreased platelet aggregation ( J:75683 )

• in response to soluble collagen, heterozygous mutant platelets show a ~5-fold right shift of the dose-response curve relative to contol platelets, indicating a partial aggregation defect

• under static conditions, heterozygous mutant platelets display normal adhesion in reponse to fibrillar collagen; however, this adhesion is significantly reduced and delayed in the presence of JAQ1 Fab fragments

• under static conditions, heterozygous mutant platelets display a reduced and delayed adhesion to soluble collagen in the absence of JAQ1-Fab fragments

homeostasis/metabolism

abnormal platelet physiology ( J:75683 )

• expression levels of integrin beta1 are decreased by ~15% whereas expression of alpha5 and alpha6 is significantly increased in heterozygous mutant platelets relative to control platelets

decreased platelet aggregation ( J:75683 )

• in response to soluble collagen, heterozygous mutant platelets show a ~5-fold right shift of the dose-response curve relative to contol platelets, indicating a partial aggregation defect

• under static conditions, heterozygous mutant platelets display normal adhesion in reponse to fibrillar collagen; however, this adhesion is significantly reduced and delayed in the presence of JAQ1 Fab fragments

• under static conditions, heterozygous mutant platelets display a reduced and delayed adhesion to soluble collagen in the absence of JAQ1-Fab fragments