Phenotypes Associated with This Genotype

Genotype
MGI:4420802

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj
• Genetic Background: B6.129-Apoe^tm1Unc Cdkn1a^tm1Tyj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:125247 )

• angiotensin II-treated mice exhibit less of an increase in mortality compared with similarly treated Apoe^tm1Unc homozygotes

cardiovascular system

decreased susceptibility to atherosclerosis ( J:125247 )

• angiotensin II-treated mice exhibit a smaller increase in plaque area, plaque grade, aortic aneurysms, atheroma, and mortality but an increase in proliferation of vascular smooth muscle cells compared with similarly treated Apoe^tm1Unc homozygotes

abnormal vascular smooth muscle physiology ( J:125247 )

• treatment with angiotensin II induces less vascular smooth muscle cell senescence and more proliferation compared to in similarly treated Apoe^tm1Unc homozygotes

increased vascular smooth muscle cell proliferation ( J:125247 )

• treatment with angiotensin II induces more vascular smooth muscle proliferation compared to in similarly treated Apoe^tm1Unc homozygotes

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:125247 )

• angiotensin II-treated mice exhibit a smaller increase in plaque area, plaque grade, aortic aneurysms, atheroma, and mortality but an increase in proliferation and decrease in senescence of vascular smooth muscle cells compared with similarly treated Apoe^tm1Unc homozygotes

cellular

increased vascular smooth muscle cell proliferation ( J:125247 )

• treatment with angiotensin II induces more vascular smooth muscle proliferation compared to in similarly treated Apoe^tm1Unc homozygotes

delayed cellular replicative senescence ( J:125247 )

• treatment with angiotensin II induces less vascular smooth muscle cell senescence compared to in similarly treated Apoe^tm1Unc homozygotes

muscle

abnormal vascular smooth muscle physiology ( J:125247 )

• treatment with angiotensin II induces less vascular smooth muscle cell senescence and more proliferation compared to in similarly treated Apoe^tm1Unc homozygotes

increased vascular smooth muscle cell proliferation ( J:125247 )

• treatment with angiotensin II induces more vascular smooth muscle proliferation compared to in similarly treated Apoe^tm1Unc homozygotes