Phenotypes Associated with This Genotype

Genotype
MGI:4420782

• Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj; Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal enterocyte proliferation ( J:111081 )

• following small bowel resection (SBR), mice fail to exhibit an increase in enterocyte proliferation unlike similarly treated wild-type mice

abnormal crypts of Lieberkuhn morphology ( J:111081 )

• following small bowel resection (SBR), mice fail to exhibit an increase in crypt depth unlike similarly treated wild-type mice

abnormal ileum morphology ( J:111081 )

• following small bowel resection (SBR), mice fail to exhibit an increase in ileal weight unlike similarly treated wild-type mice

abnormal small intestinal villus morphology ( J:111081 )

• following small bowel resection (SBR), mice fail to exhibit an increase in villus height unlike similarly treated wild-type mice

homeostasis/metabolism

abnormal response to injury ( J:111081 )

• following small bowel resection (SBR), mice fail to exhibit an increase in ileal weight, villus height, crypt depth, or enterocyte proliferation unlike similarly treated wild-type mice

• however, increase in enterocyte apoptosis following SBR is normal

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:111081 )

• following small bowel resection (SBR), mice fail to exhibit an increase in crypt depth unlike similarly treated wild-type mice

cellular

abnormal enterocyte proliferation ( J:111081 )

• following small bowel resection (SBR), mice fail to exhibit an increase in enterocyte proliferation unlike similarly treated wild-type mice