Phenotypes Associated with This Genotype

Genotype
MGI:4420547

• Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj; Cdkn1b^tm1Ako/Cdkn1b^tm1Ako
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal junctional epithelium morphology ( J:102001 )

• the total area of the periodontal junctional epithelium and connective tissue islands is larger than in wild-type or single heterozygous mice

• the total area of connective tissue islands in the junctional epithelium is larger than in wild-type and heterozygous mice

• the number of proliferating cells in the junctional epithelium is increased compared to in wild-type or single heterozygous mice

adipose tissue

increased brown adipose tissue amount ( J:118516 )

• 142% compared to in wild-type mice

increased total body fat amount ( J:118516 )

increased white fat cell number ( J:118516 )

• the number of adipocytes in the parametrial fat pad is increased 6.1-fold compared to in wild-type mice

• adipocyte hyperplasia is observed in small, medium, and large adipocytes

• the number of small adipocytes is increased 9.5-fold compared to in wild-type mice

increased inguinal fat pad weight ( J:118516 )

increased parametrial fat pad weight ( J:118516 )

• 500% at 130 days compared to in wild-type mice

behavior/neurological

increased food intake ( J:118516 )

• from 30 to 120 days, mice consume 40% more food than wild-type mice

• however, feed consumption per gram of lean body weight is normal

growth/size/body

abnormal junctional epithelium morphology ( J:102001 )

• the total area of the periodontal junctional epithelium and connective tissue islands is larger than in wild-type or single heterozygous mice

• the total area of connective tissue islands in the junctional epithelium is larger than in wild-type and heterozygous mice

• the number of proliferating cells in the junctional epithelium is increased compared to in wild-type or single heterozygous mice

increased lean body mass ( J:118516 )

• 24% at 120 days compared to in wild-type mice

increased body weight ( J:115443 , J:118516 )

• at 60 to 120 days compared with wild-type and single homozygous mice (J:118516)

increased kidney weight ( J:118516 )

• 105% compared to in wild-type mice

homeostasis/metabolism

decreased circulating testosterone level ( J:115443 )

increased circulating cholesterol level ( J:118516 )

impaired glucose tolerance ( J:118516 )

insulin resistance ( J:118516 )

liver/biliary system

hepatic steatosis ( J:118516 )

nervous system

increased brain weight ( J:118516 )

renal/urinary system

increased kidney weight ( J:118516 )

• 105% compared to in wild-type mice

craniofacial

abnormal junctional epithelium morphology ( J:102001 )

• the total area of the periodontal junctional epithelium and connective tissue islands is larger than in wild-type or single heterozygous mice

• the total area of connective tissue islands in the junctional epithelium is larger than in wild-type and heterozygous mice

• the number of proliferating cells in the junctional epithelium is increased compared to in wild-type or single heterozygous mice

endocrine/exocrine glands

decreased prostate gland anterior lobe weight ( J:115443 )

♂ • prostate gland anterior lobe weight is decreased 68% compared to in wild-type mice

decreased prostate gland dorsolateral lobe weight ( J:115443 )

♂ • prostate gland dorsolateral lobe weight is decreased 68% compared to in wild-type mice

decreased prostate gland ventral lobe weight ( J:115443 )

♂ • prostate gland ventral lobe weight is decreased 60% compared to in wild-type mice

decreased seminal vesicle weight ( J:115443 )

♂ • 75% compared to in wild-type mice

reproductive system

decreased prostate gland anterior lobe weight ( J:115443 )

♂ • prostate gland anterior lobe weight is decreased 68% compared to in wild-type mice

decreased prostate gland dorsolateral lobe weight ( J:115443 )

♂ • prostate gland dorsolateral lobe weight is decreased 68% compared to in wild-type mice

decreased prostate gland ventral lobe weight ( J:115443 )

♂ • prostate gland ventral lobe weight is decreased 60% compared to in wild-type mice

decreased seminal vesicle weight ( J:115443 )

♂ • 75% compared to in wild-type mice