Phenotypes Associated with This Genotype

Genotype
MGI:4420543

• Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj
• Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased metastatic potential ( J:83967 )

• irradiated mice develop 2.7-fold more metastatic tumors than similarly treated heterozygous mice

increased malignant tumor incidence ( J:83967 )

• irradiated mice develop multiple malignant tumors per mouse unlike similarly treated wild-type mice

increased incidence of tumors by ionizing radiation induction ( J:83967 )

• irradiated mice develop more tumors per mouse, 2.2-fold more benign tumors, multiple malignant tumors per mouse, and a broader spectrum of tumors than similarly treated wild-type mice

• irradiated mice develop 2.7-fold more metastatic tumors than similarly treated heterozygous mice

• however, the latency to tumor development and the percent of mice bearing tumors is normal