Phenotypes Associated with This Genotype

Genotype
MGI:4420468

• Allelic Composition: Rb1^tm1Tyj/Rb1^tm1Tyj; Tg(Rb1)1Blg/0
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal myogenesis ( J:65679 )

• at E18.5, myotubes express reduced levels of late muscle markers unlike wild-type myotubes

abnormal skeletal muscle fiber morphology ( J:65679 )

• at E18.5, myotubes are unable to exhibit the cell cycle, accumulate enlarged polyploidy nuclei, and express reduced levels of late muscle markers unlike wild-type myotubes

behavior/neurological

abnormal posture ( J:65679 )

hunched posture ( J:65679 )

cellular

polyploidy ( J:65679 )

• at E18.5, myotubes are polyploidy unlike wild-type myotubes

abnormal cell cycle ( J:65679 )

• at E18.5, myotubes are unable to exhibit the cell cycle and accumulate enlarged nuclei unlike wild-type myotubes