Phenotypes Associated with This Genotype

Genotype
MGI:4420430

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Nfe2l2^tm1Mym/Nfe2l2^tm1Mym
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:143903 )

• mice fed a high fat diet exhibit decreased atherosclerotic plaques compared with Apoe^tm1Unc homozygotes

abnormal aorta morphology ( J:143903 )

• mice fed a high fat diet exhibit improved aortic stiffness compared with Apoe^tm1Unc homozygotes

homeostasis/metabolism

increased circulating glucose level ( J:143903 )

• when fed a high fat diet compared with Apoe^tm1Unc homozygotes

increased circulating triglyceride level ( J:143903 )

• when fed a high fat diet compared with Apoe^tm1Unc homozygotes

cellular

oxidative stress ( J:143903 )

• mice fed a high fat diet exhibit increased oxidative stress compared with Apoe^tm1Unc homozygotes

immune system

abnormal macrophage physiology ( J:143903 )

• macrophages of mice fed a high fat diet exhibit decreased modified low density lipoprotein uptake compared to in Apoe^tm1Unc homozygotes

hematopoietic system

abnormal macrophage physiology ( J:143903 )

• macrophages of mice fed a high fat diet exhibit decreased modified low density lipoprotein uptake compared to in Apoe^tm1Unc homozygotes