Analysis Tools
mortality/aging
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• all mice fed ethanol die within 24 hours unlike similarly treated wild-type mice
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homeostasis/metabolism
hypoglycemia
(
J:136120
)
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• in moribund mice are fed ethanol unlike similarly treated wild-type mice
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• ethanol fed mice exhibit an increase in IL6 serum levels unlike similarly treated wild-type mice
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• ethanol fed mice exhibit an increase in TNF-alpha serum levels unlike similarly treated wild-type mice
• LPS-treated mice exhibit an increase in TNF-alpha serum levels unlike similarly treated wild-type mice
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• moribund ethanol fed mice exhibit an increase in alanine transaminase levels compared with similarly treated moribund wild-type mice
• ethanol fed mice treated with LPS exhibit a greater increase in alanine transaminase serum levels compared with similarly treated wild-type mice
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• mice fed ethanol exhibit mortality, cachexia, severe macrovesicular steatosis, increased apoptosis of hepatocytes, increased serum TNF-alpha and IL6 levels, focal hepatic inflammation, increased in alanine transaminase levels, and hypoglycemic serum glucose levels compared with similarly treated wild-type mice
• however, ethanol-induces oxidative damage and liver regeneration are normal
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• all mice fed ethanol die within 24 hours unlike similarly treated wild-type mice
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liver/biliary system
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• mice fed ethanol exhibit an increase in hepatocyte apoptosis compare with similarly treated wild-type mice
• LPS-treatment of ethanol fed mice increases hepatocyte apoptosis compared to in similarly treated wild-type mice
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• mice fed ethanol develop focal inflammation unlike similarly treated wild-type mice
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• moribund mice fed ethanol develop severe macrovesicular steatosis that is most prominent in the perivenous and midzonal regions compared with microvascular steatosis that develops in similarly treated wild-type mice
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immune system
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• regardless of treatment with 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl)imidazole (CDDO-Im), LPS-exposed mice exhibit a greater increase in retinal vascular leukocyte adhesion compared with similarly treated wild-type mice
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• ethanol fed mice exhibit an increase in IL6 serum levels unlike similarly treated wild-type mice
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• ethanol fed mice exhibit an increase in TNF-alpha serum levels unlike similarly treated wild-type mice
• LPS-treated mice exhibit an increase in TNF-alpha serum levels unlike similarly treated wild-type mice
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• LPS-treated mice exhibit a greater increase in reactive oxygen species in the retinal pigmented epithelium and ciliary body and retinal vascular leukocyte adhesion compared with similarly treated wild-type mice
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• mice fed ethanol develop focal inflammation unlike similarly treated wild-type mice
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growth/size/body
cellular
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• mice fed ethanol exhibit an increase in hepatocyte apoptosis compare with similarly treated wild-type mice
• LPS-treatment of ethanol fed mice increases hepatocyte apoptosis compared to in similarly treated wild-type mice
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• regardless of treatment with 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl)imidazole (CDDO-Im), LPS-exposed mice exhibit a greater increase in retinal vascular leukocyte adhesion compared with similarly treated wild-type mice
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• LPS-treated mice exhibit a greater increase in reactive oxygen species in the retinal pigmented epithelium and ciliary body compared with similarly treated wild-type mice
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hematopoietic system
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• regardless of treatment with 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl)imidazole (CDDO-Im), LPS-exposed mice exhibit a greater increase in retinal vascular leukocyte adhesion compared with similarly treated wild-type mice
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