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Phenotypes Associated with This Genotype
Genotype
MGI:4420388
Allelic
Composition		 Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfe2l2tm1Mym mutation (5 available); any Nfe2l2 mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased susceptibility to induced colitis ( J:116676 )
• DSS-treated mice exhibit a increased reduction in colon length, crypt loss, and inflammation compared with similarly treated wild-type mice

immune system
increased susceptibility to induced colitis ( J:116676 )
• DSS-treated mice exhibit a increased reduction in colon length, crypt loss, and inflammation compared with similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory