Phenotypes Associated with This Genotype

Genotype
MGI:4420329

• Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal tooth morphology ( J:95372 )

• teeth exhibit reduced acid resistance compared with wild-type teeth

abnormal incisor color ( J:95372 )

• incisors are greyish white in color unlike in wild-type mice

abnormal enamel morphology ( J:95372 )

• iron content in the enamel surface is reduced compared to in wild-type mice

ameloblast degeneration ( J:95372 )

• premature degenerative atrophy at the late maturation stage

homeostasis/metabolism

abnormal iron homeostasis ( J:95372 )

• mice exhibit defective iron transport from blood vessels to the ameloblasts compared with wild-type mice

abnormal iron level ( J:95372 )

• decreased in the enamel surface

increased liver iron level ( J:95372 )

liver/biliary system

increased liver iron level ( J:95372 )

growth/size/body

abnormal tooth morphology ( J:95372 )

• teeth exhibit reduced acid resistance compared with wild-type teeth

abnormal incisor color ( J:95372 )

• incisors are greyish white in color unlike in wild-type mice

abnormal enamel morphology ( J:95372 )

• iron content in the enamel surface is reduced compared to in wild-type mice

ameloblast degeneration ( J:95372 )

• premature degenerative atrophy at the late maturation stage

skeleton

abnormal tooth morphology ( J:95372 )

• teeth exhibit reduced acid resistance compared with wild-type teeth

abnormal incisor color ( J:95372 )

• incisors are greyish white in color unlike in wild-type mice

abnormal enamel morphology ( J:95372 )

• iron content in the enamel surface is reduced compared to in wild-type mice

ameloblast degeneration ( J:95372 )

• premature degenerative atrophy at the late maturation stage