Phenotypes Associated with This Genotype

Genotype
MGI:4420253

• Allelic Composition: Lfng^tm1Rjo/Lfng^tm1Rjo; Tg(Lfng*-LFNG)1Dihz/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Regional and dose-dependent rescue of the Lfng phenotype by transgenic expression in the stripe domain

mortality/aging

decreased survivor rate ( J:155378 )

• survival is improved compared to null mice not carrying the transgene but still less than that of wild-type controls

• relative viability compared to wild-type controls is 24%

skeleton

abnormal axial skeleton morphology ( J:155378 )

• severely disorganized and truncated axial skeleton with irregular and fused vertebrae and vertebral bodies that rarely align with the midline

abnormal vertebral column morphology ( J:155378 )

abnormal thoracic vertebrae morphology ( J:155378 )

• slight restoration of thoracic vertebrae morphology compared to null mice not carrying the transgene

abnormal cervical vertebrae morphology ( J:155378 )

• slight restoration of cervical vertebrae morphology compared to null mice not carrying the transgene

abnormal lumbar vertebrae morphology ( J:155378 )

• slight restoration of lumbar vertebrae morphology compared to null mice not carrying the transgene

short vertebral column ( J:155378 )

• truncated axial skeleton

limbs/digits/tail

short tail ( J:155378 )

• tails are longer than in null mice not carrying the transgene but still shorter than in wild-type controls