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Phenotypes Associated with This Genotype
Genotype
MGI:4418907
Allelic
Composition		 Esr2tm1Unc/Esr2tm1Unc
Inhatm1Bay/Inhatm1Bay
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr2tm1Unc mutation (4 available); any Esr2 mutation (35 available)
Inhatm1Bay mutation (0 available); any Inha mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:84989 )
• all mice die by 20 weeks of age similar to Inhatm1Bay homozygotes

neoplasm
increased ovary tumor incidence ( J:84989 )
• similar to Inhatm1Bay homozygotes
increased testis tumor incidence ( J:84989 )
• similar to Inhatm1Bay homozygotes

digestive/alimentary system
abnormal stomach morphology ( J:84989 )
• mice develop hallmarks of disease progression that are similar to in Inhatm1Bay homozygotes

growth/size/body
cachexia ( J:84989 )
• similar to Inhatm1Bay homozygotes

liver/biliary system
abnormal liver morphology ( J:84989 )
• mice develop hallmarks of disease progression that are similar to in Inhatm1Bay homozygotes

endocrine/exocrine glands
increased ovary tumor incidence ( J:84989 )
• similar to Inhatm1Bay homozygotes
increased testis tumor incidence ( J:84989 )
• similar to Inhatm1Bay homozygotes

reproductive system
increased ovary tumor incidence ( J:84989 )
• similar to Inhatm1Bay homozygotes
increased testis tumor incidence ( J:84989 )
• similar to Inhatm1Bay homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory