Phenotypes Associated with This Genotype

Genotype
MGI:4418905

• Allelic Composition: Esr1^tm1Ksk/Esr1^tm1Ksk; Inha^tm1Bay/Inha^tm1Bay
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:84989 )

• male mice exhibit reduced survival compared with Esr1^tm1Ksk homozygotes that is similar to in Inha^tm1Bay homozygotes

• female mice exhibit reduced survival compared with Esr1^tm1Ksk or Inha^tm1Bay homozygotes

neoplasm

increased ovary tumor incidence ( J:84989 )

♀ • tumors are larger than in Inha^tm1Bay homozygotes

♀ • tumors contain tubule-like follicle-like structures

increased testis tumor incidence ( J:84989 )

♂ • tumor cells contain diffuse granulosa-like cells

growth/size/body

decreased body weight ( J:84989 )

• in female mice compared with Esr1^tm1Ksk homozygotes, Inha^tm1Bay homozygotes, and wild-type mice

cachexia ( J:84989 )

• mice develop rapid cancer-associated wasting unlike wild-type mice that is more severe than in Inha^tm1Bay homozygotes

homeostasis/metabolism

increased circulating estradiol level ( J:84989 )

decreased circulating follicle stimulating hormone level ( J:84989 )

• in terminal mice compared with Inha^tm1Bay homozygotes

decreased circulating luteinizing hormone level ( J:84989 )

• in terminal mice compared with Inha^tm1Bay homozygotes

digestive/alimentary system

abnormal stomach mucosa morphology ( J:84989 )

• terminal mice exhibit mucosal atrophy in the stomach unlike in wild-type mice

abnormal stomach glandular epithelium morphology ( J:84989 )

• terminal mice exhibit depletion of parietal cells in the glandular stomach unlike in wild-type mice

immune system

liver inflammation ( J:84989 )

liver/biliary system

liver inflammation ( J:84989 )

abnormal hepatocyte morphology ( J:84989 )

• hepatocytes in terminal mice are darkened irregularly shaped and round surrounding the central vein unlike in wild-type mice

hepatic necrosis ( J:84989 )

• in terminal mice

skeleton

kyphoscoliosis ( J:84989 )

• in terminal mice

endocrine/exocrine glands

increased ovary tumor incidence ( J:84989 )

♀ • tumors are larger than in Inha^tm1Bay homozygotes

♀ • tumors contain tubule-like follicle-like structures

increased testis tumor incidence ( J:84989 )

♂ • tumor cells contain diffuse granulosa-like cells

reproductive system

increased ovary tumor incidence ( J:84989 )

♀ • tumors are larger than in Inha^tm1Bay homozygotes

♀ • tumors contain tubule-like follicle-like structures

increased testis tumor incidence ( J:84989 )

♂ • tumor cells contain diffuse granulosa-like cells