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Phenotypes Associated with This Genotype
Genotype
MGI:4418552
Allelic
Composition
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
Genetic
Background
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1atm3Rsjo mutation (3 available); any Hif1a mutation (50 available)
Tg(SFTPC-rtTA)5Jaw mutation (5 available)
Tg(tetO-cre)1Jaw mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice die within an hour of birth when exposed to doxycycline 8 days prior to parturition
• 85% of mice die within an hour of birth when exposed to doxycycline 4 of 6 days prior to parturition

respiratory system
• at birth when mice are exposed to doxycycline prior to parturition
• when mice are exposed to doxycycline prior to parturition, mice exhibit reduced alveolar airspaces unlike wild-type mice
• when mice are exposed to doxycycline prior to parturition, the alveolar surface is lined with immature pneumocytes unlike in wild-type mice
• when mice are exposed to doxycycline prior to parturition, the alveolar septa has only a few scattered type II cells unlike in wild-type mice
• at birth when mice are exposed to doxycycline prior to parturition
• at birth when mice are exposed to doxycycline prior to parturition
• at birth when mice are exposed to doxycycline prior to parturition
• when mice are exposed to doxycycline prior to parturition

homeostasis/metabolism
• at birth when mice are exposed to doxycycline prior to parturition

growth/size/body
• at birth when mice are exposed to doxycycline prior to parturition


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/20/2026
MGI 6.24
The Jackson Laboratory