Phenotypes Associated with This Genotype

Genotype
MGI:4418547

• Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo; Tg(Pax6-cre,GFP)1Pgr/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased lens fiber apoptosis ( J:141905 )

• at 1 month of age

abnormal lens morphology ( J:141905 )

• although born with normal lenses, mice exhibit lens degeneration after 1 month unlike wild-type mice

abnormal lens fiber morphology ( J:141905 )

• at 1 month of age, fiber cells are swollen and disorganized with many apoptotic nuclei unlike in wild-type mice

small lens ( J:141905 )

• at 1 month of age

cellular

increased lens fiber apoptosis ( J:141905 )

• at 1 month of age