Phenotypes Associated with This Genotype

Genotype
MGI:4418481

• Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo; Myl2^tm1(cre)Krc/Myl2⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal coronary vessel morphology ( J:118455 )

• fewer blood vessels are present in the left ventricle compared to in wild-type mice

thick interventricular septum ( J:118455 )

• the diastolic thickness of the intraventricular septum is increased compared to in wild-type mice

cardiac hypertrophy ( J:118455 )

• mild

abnormal heart left ventricle morphology ( J:118455 )

• left ventricular end-diastolic diameter is reduced compared to in wild-type mice

increased heart left ventricle weight ( J:118455 )

increased heart left ventricle wall thickness ( J:118455 )

• the diastolic thickness of the left ventricle is increased compared to in wild-type mice

decreased cardiac muscle contractility ( J:118455 )

• mice exhibit reduced fractional shortening compared with wild-type mice

• during electrical stimulation, cardiomyocytes exhibit reduced cell shortening compared with wild-type cells

abnormal cardiac muscle relaxation ( J:118455 )

• dobutamine-treated mice exhibit increased isovolumic relaxation time, a measure of diastolic dysfunction, compared to in similarly treated wild-type mice

abnormal heart left ventricle pressure ( J:118455 )

• mice exhibit reduced maximum rates of left ventricular pressure development and pressure decline compared to in wild-type mice

abnormal myocardial fiber physiology ( J:118455 )

• cardiomyocytes exhibit prolonged time to reduce cytosolic calcium levels compared with wild-type cells

growth/size/body

cardiac hypertrophy ( J:118455 )

• mild

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:118455 )

• dobutamine-treated mice exhibit increased isovolumic relaxation time, a measure of diastolic dysfunction, compared to in similarly treated wild-type mice

muscle

decreased cardiac muscle contractility ( J:118455 )

• mice exhibit reduced fractional shortening compared with wild-type mice

• during electrical stimulation, cardiomyocytes exhibit reduced cell shortening compared with wild-type cells

abnormal cardiac muscle relaxation ( J:118455 )

• dobutamine-treated mice exhibit increased isovolumic relaxation time, a measure of diastolic dysfunction, compared to in similarly treated wild-type mice