Phenotypes Associated with This Genotype

Genotype
MGI:4418454

• Allelic Composition: Tg(Camk2a-KCNH3)1Akmi/?
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal long-term object recognition memory ( J:155749 )

• no improvement in performance in a water finding task after training

abnormal spatial reference memory ( J:155749 )

• poor spatial reference memory

• shorter time spent in the target quadrant of a water maze

• no improvement in escape latency in a water maze

abnormal spatial working memory ( J:155749 )

• impaired working memory

• lower rate of alternation between arms

• arm entry frequency similar to controls when tested in a "Y" maze

nervous system

reduced long-term potentiation ( J:155749 )

• tetanus induced LTP is reduced