Phenotypes Associated with This Genotype

Genotype
MGI:4418371

• Allelic Composition: Tg(Mt1-RET)304Ina/0
• Genetic Background: B6.C-Tg(Mt1-RET)304Ina

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased cutaneous melanoma incidence ( J:50392 )

• mice develop benign skin melanocytic tumors that progress to malignant melanomas

• tumors metastasize to the lymph nodes, lung, brain, kidney, liver, and spleen

• Background Sensitivity: tumors are more prevalent on a predominantly C57BL/6 background compared with in mice on a predominantly BALB/c background

• however, mice are tumor free for 100 days

pigmentation

hyperpigmentation ( J:50392 )

• mice exhibit melanosis throughout their life

integument

increased cutaneous melanoma incidence ( J:50392 )

• mice develop benign skin melanocytic tumors that progress to malignant melanomas

• tumors metastasize to the lymph nodes, lung, brain, kidney, liver, and spleen

• Background Sensitivity: tumors are more prevalent on a predominantly C57BL/6 background compared with in mice on a predominantly BALB/c background

• however, mice are tumor free for 100 days

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
skin melanoma		DOID:8923	OMIM:608035 OMIM:612263	J:50392