Phenotypes Associated with This Genotype

Genotype
MGI:4418310

• Allelic Composition: Adam8^tm1.1Mdz/Adam8^tm1.1Mdz
• Genetic Background: DBA/1LacJ-Adam8^tm1.1Mdz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:155243 )

N • normal response to lipopolysaccheride challenge

decreased susceptibility to induced arthritis ( J:155243 )

• incidence and severity of lipopolysaccharide-synchronized collagen-induced arthritis are significantly reduced

• inflammation and cartilage degradation are significantly less severe

• less severe synovial inflammation and cartilage erosion

skeleton

decreased susceptibility to induced arthritis ( J:155243 )

• incidence and severity of lipopolysaccharide-synchronized collagen-induced arthritis are significantly reduced

• inflammation and cartilage degradation are significantly less severe

• less severe synovial inflammation and cartilage erosion