Phenotypes Associated with This Genotype

Genotype
MGI:4418248

• Allelic Composition: Lfng^tm1.2Egan/Lfng^tm1.2Egan
• Genetic Background: FVB.129-Lfng^tm1.2Egan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung vasculature morphology ( J:155893 )

• mice exhibit reduced lung vascular branching compared to in wild-type mice

abnormal lung development ( J:155893 )

• Background Sensitivity: abnormal lung development is more severe on an FVB background

• mice exhibit altered lung patterning and reduced lung vascular branching compared to in wild-type mice

• at E16.5, saccule expansion is delayed compared to in wild-type mice

• at E18.5, saccules are less opened than in wild-type mice

• in late embryogenesis, myofibroblast progenitors in the lungs exhibit defective differentiation marked by sma+ expression compared to in wild-type mice

• however, myofibroblast progenitor cell specification and spreading in the lungs are normal

abnormal pulmonary alveolus morphology ( J:155893 )

• mice exhibit thickened alveolar walls, lack of alveolar septation, and large alveolar size compared with wild-type mice

skeleton

abnormal rib development ( J:155893 )

• rib patterning is abnormal

limbs/digits/tail

short tail ( J:155893 )

cardiovascular system

abnormal lung vasculature morphology ( J:155893 )

• mice exhibit reduced lung vascular branching compared to in wild-type mice