Phenotypes Associated with This Genotype

Genotype
MGI:4418210

• Allelic Composition: Gata4^tm1Jml/Gata4⁺; Gata5^tm1Eem/Gata5^tm1Eem
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ventriclular abnormalities in Gata4^tm1Jml/Gata4⁺ Gata5^tm1Eem/Gata5^tm1Eem and Gata4^tm1Jml/Gata4⁺ Gata5^tm1Eem/Gata5⁺ mice

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:155855 )

• mice do not survive past E14.5 with no live mice found in newborn litters

cardiovascular system

abnormal trabecula carnea morphology ( J:155855 )

• fine, abnormal trabecular structures

thin ventricle myocardium compact layer ( J:155855 )

• at E12.5, the thickness of the ventricular compact myocardial layer is reduced 61% compared to in wild-type mice

• at E14.5, the ventricular compact myocardial layer thickness is reduced 84% compared to in wild-type mice

ventricular myocardium compact layer hypoplasia ( J:155855 )

conotruncal ridge hypoplasia ( J:155855 )

• conotruncal cushions are reduced in size and altered in location compared to in wild-type mice leading to abnormalities in ventriculoarterial positioning

atrioventricular cushion hypoplasia ( J:155855 )

• endocardial cushions are hypoplastic at E12.5

ostium primum atrial septal defect ( J:155855 )

• mice exhibit a primum atrial septal defect unlike wild-type mice

complete atrioventricular septal defect ( J:155855 )

• mice exhibit a common atrioventricular canal and occasionally an unbalanced canal leading to a functionally univentricular heart

unbalanced complete common atrioventricular canal ( J:155855 )

• occasionally

inlet ventricular septal defect ( J:155855 )

• mice exhibit large inlet-type ventricular septal defect

abnormal heart left ventricle outflow tract morphology ( J:155855 )

• mice exhibit moderately hypoplastic and anteriorly malaligned left ventricular outflow tracts

abnormal heart right ventricle outflow tract morphology ( J:155855 )

• the right ventricular outflow tract is more posteriorly positioned than in wild-type mice

thin ventricular wall ( J:155855 )

• mice exhibit a thinning of the ventricular wall

hemorrhage ( J:155855 )

• at E14.5, mice exhibit systemic hemorrhage

decreased fetal cardiomyocyte proliferation ( J:155855 )

• proliferation of cells in the ventricular myocardium is reduced by 51% at E12.5 and 55% at E14.5 compared to in wild-type mice

• however, apoptosis rates are normal

congestive heart failure ( J:155855 )

• at E14.5

homeostasis/metabolism

edema ( J:155855 )

• at E14.5, mice exhibit body wall edema

muscle

abnormal trabecula carnea morphology ( J:155855 )

• fine, abnormal trabecular structures

thin ventricle myocardium compact layer ( J:155855 )

• at E12.5, the thickness of the ventricular compact myocardial layer is reduced 61% compared to in wild-type mice

• at E14.5, the ventricular compact myocardial layer thickness is reduced 84% compared to in wild-type mice

ventricular myocardium compact layer hypoplasia ( J:155855 )

decreased fetal cardiomyocyte proliferation ( J:155855 )

• proliferation of cells in the ventricular myocardium is reduced by 51% at E12.5 and 55% at E14.5 compared to in wild-type mice

• however, apoptosis rates are normal

cellular

decreased fetal cardiomyocyte proliferation ( J:155855 )

• proliferation of cells in the ventricular myocardium is reduced by 51% at E12.5 and 55% at E14.5 compared to in wild-type mice

• however, apoptosis rates are normal