Phenotypes Associated with This Genotype

Genotype
MGI:4418046

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Cav1^tm1Mls/Cav1^tm1Mls
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:101788 )

• 70% reduction in atherosclerotic lesion area, indicating protection against the development of aortic atheromas

homeostasis/metabolism

increased circulating cholesterol level ( J:101788 )

• 1.3 to 1.5-fold increase in non-HDL plasma cholesterol levels when fed a normal or high-fat diet

increased circulating LDL cholesterol level ( J:101788 )

• on a normal or high-fat diet

increased circulating VLDL cholesterol level ( J:101788 )

• on a normal or high-fat diet

increased circulating triglyceride level ( J:101788 )

• approximate 2.3-fold increase in plasma triglyceride when fed a normal or high-fat diet