Phenotypes Associated with This Genotype

Genotype
MGI:4418043

• Allelic Composition: Gata3^tm2Jeng/Gata3^tm2Jeng
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:155686 )

immune system

abnormal T cell differentiation ( J:155686 )

• reduced numbers of early T cell progenitors at E18.5 and E15.5

decreased double-negative T cell number ( J:155686 )

• at E18.5 and E15.5

abnormal double-positive T cell morphology ( J:155686 )

• delayed generation of double positive T-cells

abnormal T cell number ( J:155686 )

• ratios of CD4+, CD8+, double positive, and double negative thymocytes past stage 3 are normal

decreased thymocyte number ( J:155686 )

• reduced to about one third of control mouse levels at E15.5 and E18.5

decreased gamma-delta T cell number ( J:155686 )

• reduced absolute numbers

hematopoietic system

abnormal T cell differentiation ( J:155686 )

• reduced numbers of early T cell progenitors at E18.5 and E15.5

abnormal double-positive T cell morphology ( J:155686 )

• delayed generation of double positive T-cells

abnormal T cell number ( J:155686 )

• ratios of CD4+, CD8+, double positive, and double negative thymocytes past stage 3 are normal

decreased thymocyte number ( J:155686 )

• reduced to about one third of control mouse levels at E15.5 and E18.5

decreased double-negative T cell number ( J:155686 )

• at E18.5 and E15.5

decreased gamma-delta T cell number ( J:155686 )

• reduced absolute numbers

endocrine/exocrine glands

decreased thymocyte number ( J:155686 )

• reduced to about one third of control mouse levels at E15.5 and E18.5