Phenotypes Associated with This Genotype

Genotype
MGI:4417937

• Allelic Composition: Tg(KRT14-Fyn*)aJsey/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin squamous cell carcinoma incidence ( J:155536 )

• 15 out of 116 transgenic mice develop spontaneous squamous cell carcinomas (SCC) between ages 3 and 7 months

• enlarged keratinocytes with nuclear atypia, mitotic activity, dermal invasion, and focal keratinization

integument

abnormal keratinocyte morphology ( J:155536 )

• cytologic atypia and architectural disorganization in hyperkeratotic plaques

• increased mitotic activity in hyperkeratotic plaques

• enlarged keratinocytes with nuclear atypia, mitotic activity, dermal invasion, and focal keratinization in SCC

epidermal hyperplasia ( J:155536 )

• 72 out of 116 transgenic mice develop multiple hyperkeratotic plaques in the epidermis

• detectable at ages 3 to 4 days and persist until ages 3 to 4 weeks

thick epidermis ( J:155536 )

• markedly thickened epidermis in hyperkeratotic plaques

increased skin squamous cell carcinoma incidence ( J:155536 )

• 15 out of 116 transgenic mice develop spontaneous squamous cell carcinomas (SCC) between ages 3 and 7 months

• enlarged keratinocytes with nuclear atypia, mitotic activity, dermal invasion, and focal keratinization