Phenotypes Associated with This Genotype

Genotype
MGI:4417904

• Allelic Composition: Junb^tm3Wag/Junb^tm3Wag; Tg(KRT5-cre)1Tak/0
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:155575 )

• mice die before 20 months

immune system

increased plasma cell number ( J:155575 )

• mice exhibit an increase in plasma cells in the blood, lymph node and spleen unlike wild-type mice

increased IgE level ( J:155575 )

increased circulating interleukin-6 level ( J:155575 )

increased interleukin-6 secretion ( J:155575 )

• from epidermal cells

increased susceptibility to systemic lupus erythematosus ( J:155575 )

• mice exhibit skin ulcerations, the lupus band in the epidermal-dermal junction, increased IL-6 secretion, mesangial hypercellularity with glomerular basement membrane thickening and luminal obstruction, small and strophic kidney, increased anti-histone antibodies, and decreased survival compared with wild-type mice

increased anti-histone antibody level ( J:155575 )

increased inflammatory response ( J:155575 )

• UV-treated mice exhibit inflammatory perivascular infiltrates with abundant CD3+ T lymphocytes in the liver and lungs unlike similarly treated Junb^tm3Wag homozygotes

• UV-treated mice develop swelling of the paws with functional articular impairment, synovial proliferation, and synovial membrane inflammation unlike similarly treated Junb^tm3Wag homozygotes

glomerulonephritis ( J:155575 )

• unlike wild-type controls, mice develop immunocomplex glomerulonephritis (IC-GN) characterized by mesangial hypercellularity, lobulation of the glomerular tuft with basement membrane thickening, endocapillary hypercellularity, and luminal obstruction by immuno complex deposits

• UV-treated mice develop IC-GN accompanied by tubulo-interstitial nephritis and perivascular CD3+ T-cell-rich infiltrates unlike similarly treated Junb^tm3Wag homozygotes

tubulointerstitial nephritis ( J:155575 )

• UV-treated mice develop IC-GN accompanied by tubulo-interstitial nephritis and perivascular CD3+ T-cell-rich infiltrates unlike similarly treated Junb^tm3Wag homozygotes

dermatitis ( J:155575 )

• starting at 3 months, mice exhibit dermatitis of ears, snouts, upper thorax region, and paws unlike wild-type mice

renal/urinary system

abnormal glomerular capillary morphology ( J:155575 )

• mice display endocapillary hypercellularity and luminal obstruction by immuno complex deposits

increased mesangial cell number ( J:155575 )

• mice exhibit mesangial hypercellularity

albuminuria ( J:155575 )

glomerulonephritis ( J:155575 )

• unlike wild-type controls, mice develop immunocomplex glomerulonephritis (IC-GN) characterized by mesangial hypercellularity, lobulation of the glomerular tuft with basement membrane thickening, endocapillary hypercellularity, and luminal obstruction by immuno complex deposits

• UV-treated mice develop IC-GN accompanied by tubulo-interstitial nephritis and perivascular CD3+ T-cell-rich infiltrates unlike similarly treated Junb^tm3Wag homozygotes

tubulointerstitial nephritis ( J:155575 )

• UV-treated mice develop IC-GN accompanied by tubulo-interstitial nephritis and perivascular CD3+ T-cell-rich infiltrates unlike similarly treated Junb^tm3Wag homozygotes

podocyte foot process effacement ( J:155575 )

• mice exhibit podocyte foot process effacement in most glomerular capillary loops

increased renal glomerulus basement membrane thickness ( J:155575 )

• mice exhibit GBM thickening

increased renal glomerulus lobularity ( J:155575 )

• mice exhibit lobulation of the glomerular tuft

renal glomerular immunoglobulin deposits ( J:155575 )

small kidney ( J:155575 )

kidney atrophy ( J:155575 )

homeostasis/metabolism

increased circulating interleukin-6 level ( J:155575 )

albuminuria ( J:155575 )

hematopoietic system

increased plasma cell number ( J:155575 )

• mice exhibit an increase in plasma cells in the blood, lymph node and spleen unlike wild-type mice

increased IgE level ( J:155575 )

integument

dermatitis ( J:155575 )

• starting at 3 months, mice exhibit dermatitis of ears, snouts, upper thorax region, and paws unlike wild-type mice

abnormal epidermal-dermal junction morphology ( J:155575 )

• mice exhibit the lupus band in the epidermal-dermal junction unlike wild-type mice

spontaneous skin ulceration ( J:155575 )

• at 3 months

thick skin ( J:155575 )

cardiovascular system

abnormal glomerular capillary morphology ( J:155575 )

• mice display endocapillary hypercellularity and luminal obstruction by immuno complex deposits

cellular

increased mesangial cell number ( J:155575 )

• mice exhibit mesangial hypercellularity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:155575