Phenotypes Associated with This Genotype

Genotype
MGI:4417872

• Allelic Composition: Prkci^tm1Kido/Prkci^tm1Kido; Tg(Cryaa-cre)10Mlr/?
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal anterior eye segment morphology ( J:154910 )

abnormal iris morphology ( J:154910 )

abnormal iris pigment epithelium ( J:154910 )

• pigment cells cover the surface of the lens

pupil opacity ( J:154910 )

• small opaque pupils speckled with black material

small pupil ( J:154910 )

abnormal lens morphology ( J:154910 )

• lenses are still normal at E10.5

• lens vesicle closes normally at E11.5

abnormal lens epithelium morphology ( J:154910 )

• lens epithelium layer thinner at E18.5 than for controls

• reduced cell proliferation in germinative zone of the lens epithelium

• increased expression of alpha smooth muscle actin in lens epithelia after E16.5

disorganized secondary lens fibers ( J:154910 )

• fiber cell alignment severely disrupted at E18.5

• youngest lens fiber cells have lost apical connections

• interface between lens epithelial cells and fiber cells is much shorter at E12.5

microphthalmia ( J:154910 )

• small almond shaped eyes

• smaller eyeball

pigmentation

abnormal iris pigment epithelium ( J:154910 )

• pigment cells cover the surface of the lens