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Phenotypes Associated with This Genotype
Genotype
MGI:4417866
Allelic
Composition
Dnajc3tm8663Wcl/Dnajc3tm8663Wcl
Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnajc3tm8663Wcl mutation (1 available); any Dnajc3 mutation (25 available)
Sil1Gt(RST462)Byg mutation (0 available); any Sil1 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• at 20 weeks, mice exhibit a normal rear stance width unlike Sil1Gt(RST462)Byg homozygotes

nervous system
• at 4 months of age, mice begin to exhibit Purkinje cell degeneration
• however, by 8 months most Purkinje cells remain intact and few Purkinje cells exhibit ubiquitin+ inclusions


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory