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Phenotypes Associated with This Genotype
Genotype
MGI:4417863
Allelic
Composition		 Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic
Background		 B6.129P2-Sil1Gt(RST462)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sil1Gt(RST462)Byg mutation (0 available); any Sil1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal Purkinje cell morphology ( J:154993 )
• at 10 weeks, Purkinje cells accumulate ubiquitin+ inclusions, a marker of endoplasmic reticulum stress

behavior/neurological
ataxia ( J:154993 )
• at 3 and 4 months of age
abnormal posture ( J:154993 )
• at 20 weeks, mice exhibit a wide stance compared with wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory