Phenotypes Associated with This Genotype

Genotype
MGI:4417842

• Allelic Composition: Il15ra^tm1Ama/Il15ra^tm2.1Ama; Tg(Itgax-cre)1-1Reiz/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal NK cell differentiation ( J:155298 )

• increase in immature CD11b+ CXCR3+ NK cells in spleen and bone marrow

• more mature KLRG-1+ CD11b+ NK cells are underrepresented in spleen and bone marrow

decreased NK cell number ( J:155298 )

• about half the number of NK cells in the spleen, lymph node, liver, and lung

• but no decrease is seen in the bone marrow

abnormal T cell subpopulation ratio ( J:155298 )

• marked decrease in the ratio of CD62L^hi to CD62L^lo memory phenotype CD8+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:155298 )

• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood

• marked decrease in the number of CD62L^hi memory phenotype CD8+ T cells

decreased memory T cell number ( J:155298 )

• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood

• marked decrease in the number of CD62L^hi memory phenotype CD8+ T cells

abnormal NK cell physiology ( J:155298 )

• decrease in proliferation of CD27+ CD11b+ cells

• decrease in activation of adoptively transferred wild-type NK cells in response to lipopolysaccaride

immune system

abnormal NK cell differentiation ( J:155298 )

• increase in immature CD11b+ CXCR3+ NK cells in spleen and bone marrow

• more mature KLRG-1+ CD11b+ NK cells are underrepresented in spleen and bone marrow

decreased NK cell number ( J:155298 )

• about half the number of NK cells in the spleen, lymph node, liver, and lung

• but no decrease is seen in the bone marrow

abnormal T cell subpopulation ratio ( J:155298 )

• marked decrease in the ratio of CD62L^hi to CD62L^lo memory phenotype CD8+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:155298 )

• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood

• marked decrease in the number of CD62L^hi memory phenotype CD8+ T cells

decreased memory T cell number ( J:155298 )

• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood

• marked decrease in the number of CD62L^hi memory phenotype CD8+ T cells

abnormal NK cell physiology ( J:155298 )

• decrease in proliferation of CD27+ CD11b+ cells

• decrease in activation of adoptively transferred wild-type NK cells in response to lipopolysaccaride