Phenotypes Associated with This Genotype

Genotype
MGI:4415726

• Allelic Composition: Nrdc^tm1Eiin/Nrdc^tm1Eiin
• Genetic Background: B6.Cg-Nrdc^tm1Eiin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:155532 )

• 80% of mice die within the first 48 hours after birth

nervous system

decreased brain weight ( J:155532 )

• 29% lower than in wild-type mice at P90

enlarged lateral ventricles ( J:155532 )

• at P90

abnormal cerebral cortex morphology ( J:155532 )

• at P90, the neuronal cell density in the cortex is greater than in wild-type mice

• at P90, mice exhibit cortical shrinkage compared with wild-type mice

thin cerebral cortex ( J:155532 )

• at P90

abnormal axon morphology ( J:155532 )

• mice exhibit impaired axonal maturation in the central and peripheral nervous system compared with wild-type mice

abnormal myelin sheath morphology ( J:155532 )

• at P30 and P365, the thickness of myelin sheaths is reduced compared to in wild-type mice

• however, differentiation of oligodendrocytes is normal

abnormal sciatic nerve morphology ( J:155532 )

• at P30 and P365, the nerves in the Remak bundles of the sciatic nerve is two-fold more than in wild-type mice

abnormal myelination ( J:155532 )

• mice exhibit hypomyelination of axons in the cortex, hippocampus, and corpus callosum compared with wild-type mice

• mice exhibit delayed initiation of myelination and hypomyelination in the central and peripheral nervous system

• at P14, only one seventh of axons are myelinated unlike in wild-type mice

• at P90, only 21% of axons are myelinated unlike in wild-type mice

• however, differentiation of oligodendrocytes is normal

behavior/neurological

abnormal spatial working memory ( J:155532 )

• mice exhibit reduced correct choices in a forced-alternation task compared with wild-type mice

• however, reference memory is normal

limb grasping ( J:155532 )

impaired coordination ( J:155532 )

• in a beam test, mice move slower and slip more frequently than wild-type mice

• mice exhibit reduced latency to fall on a rotarod compared with wild-type mice

decreased grip strength ( J:155532 )

• mice exhibit reduced grip strength compared with wild-type mice

• however, mice exhibit normal behavior in a wire-hanging test

growth/size/body

decreased birth weight ( J:155532 )

• 30% less than wild-type mice

decreased body size ( J:155532 )

• surviving mice remain smaller than wild-type mice