Phenotypes Associated with This Genotype

Genotype
MGI:4415279

• Allelic Composition: Cacna1a^tm2Nobs/Cacna1a^tm2Nobs
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:155607 )

N • mice exhibit normal a lifespan

nervous system

clonic seizures ( J:155607 )

absence seizures ( J:155607 )

abnormal spike wave discharge ( J:155607 )

cerebellum atrophy ( J:155607 )

• at 2 months, mice exhibit progressive cerebellar atrophy via apoptosis in the granular layer

behavior/neurological

ataxia ( J:155607 )

• at 10 to 12 days

impaired coordination ( J:155607 )

• mice exhibit impaired performance on a rotarod compared with wild-type mice

clonic seizures ( J:155607 )

absence seizures ( J:155607 )

abnormal spike wave discharge ( J:155607 )