Phenotypes Associated with This Genotype

Genotype
MGI:4415253

• Allelic Composition: Kcnc1^tm1Joho/Kcnc1⁺; Kcnc3^tm1Echa/Kcnc3⁺
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:71179 )

N • unlike double mutant mice, double-heterozygous mice display neither signs of ataxia, tremors, whole-body jerks and myoclonus nor increased ethanol sensitivity relative to wild-type control mice

increased exploration in new environment ( J:71179 )

• unlike wild-type mice which spend for most of their time in the corners of an open field with only brief excursions to the center, all double-heterozygous mice spend more time along the edges and show a similar increase in center-field occupancy relative to double mutant mice

increased locomotor activity ( J:71179 )

• in the open field, some double-heterozygous mice display spontaneous locomotor activity intermediate between that of wild-type and double-mutant mice

• increased spontaneous locomotion is directly related to a significant increase in ambulatory time during the 60 min test period; however, the traveling speed, remains unchanged

growth/size/body

decreased body weight ( J:71179 )

• at P45 and P100, some double-heterozygous mice reach only 10%-15% of the body weight of wild-type control mice