Phenotypes Associated with This Genotype

Genotype
MGI:4414943

• Allelic Composition: Gli2^{tm5.1(GLI3)Alj}/Gli2^{tm5.1(GLI3)Alj}; Gli3^Xt/Gli3^Xt
• Genetic Background: involves: 101/H * C3H/HeH * C57BL * CBA/H * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

absent floor plate ( J:87948 )

• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord

abnormal ventral interneuron 3 morphology ( J:87948 )

• decrease in number of V3 interneurons that occupy the ventral midline

embryo

absent floor plate ( J:87948 )

• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord

limbs/digits/tail

limbs/digits/tail phenotype ( J:87948 )

N • almost complete rescue of the pre-axial limb polydactyly observed in Gli3 mutants