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Phenotypes Associated with This Genotype
Genotype
MGI:4414856
Allelic
Composition		 Lrp5Gt(OST164883)Lex/Lrp5+
Tspan12tm1Wye/Tspan12+
Genetic
Background		 either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5Gt(OST164883)Lex mutation (1 available); any Lrp5 mutation (81 available)
Tspan12tm1Wye mutation (0 available); any Tspan12 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:154863 )
• at P14 and P15, retinal vertical sprouts are reduced compared to in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice

vision/eye
abnormal retina vasculature morphology ( J:154863 )
• at P14 and P15, retinal vertical sprouts are reduced compared to in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory