Phenotypes Associated with This Genotype

Genotype
MGI:4414762

• Allelic Composition: Paqr3^tm1Ychn/Paqr3⁺
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:139058 )

• papillomas begin to appear at 12 weeks post DMBA (7, 12-dimethylbenz(a) anthracene) and TPA (12-O-tetradecanoylphorbol-13-acetate) treatment compared to 15 weeks in wild-type mice

• the proportion of mice that develop papillomas after DMBA and TPA treatment is increased

increased skin papilloma incidence ( J:139058 )

• the number of DMBA and TPA induced papillomas per mouse is markedly increased

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:139058 )

• papillomas begin to appear at 12 weeks post DMBA (7, 12-dimethylbenz(a) anthracene) and TPA (12-O-tetradecanoylphorbol-13-acetate) treatment compared to 15 weeks in wild-type mice

• the proportion of mice that develop papillomas after DMBA and TPA treatment is increased

integument

increased skin papilloma incidence ( J:139058 )

• the number of DMBA and TPA induced papillomas per mouse is markedly increased