Phenotypes Associated with This Genotype

Genotype
MGI:4414677

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Gli2*)Flng}/Gt(ROSA)26Sor⁺; Ihh^tm1Amc/Ihh^tm1Amc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoblast differentiation ( J:154905 )

• orthotopic osteoblast differentiation is impaired as determined by marker expression

abnormal long bone epiphyseal plate proliferative zone ( J:154905 )

• decreased at E18.5

abnormal long bone hypertrophic chondrocyte zone ( J:154905 )

• the hypertrophic zone lacks vascularization unlike in wild-type mice

disorganized long bone epiphyseal plate ( J:154905 )

• columnar organization prior to hypertrophy is absent unlike in wild-type mice

cellular

abnormal osteoblast differentiation ( J:154905 )

• orthotopic osteoblast differentiation is impaired as determined by marker expression