Phenotypes Associated with This Genotype

Genotype
MGI:4414675

• Allelic Composition: Gli3^Xt-J/Gli3^Xt-J; Gt(ROSA)26Sor^{tm2(Gli2*)Flng}/Gt(ROSA)26Sor⁺; Ihh^tm1Amc/Ihh^tm1Amc; Tg(Col2a1-cre)3Amc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:154905 )

• mice die at birth

skeleton

skeleton phenotype ( J:154905 )

N • unlike in Ihh^tm1Amc Gli3^Xt-J homozygotes the marrow cavity and hypertrophic chondrocyte are normal

abnormal long bone diaphysis morphology ( J:154905 )

• the growth region cartilage is longer than in wild-type mice

• the columnar zone contains areas of disorganization unlike in wild-type mice

• however, orthotopic bone collar formation is normal unlike in Ihh^tm1Amc homozygotes

growth/size/body

decreased body size ( J:154905 )

• while larger than Ihh^tm1Amc homozygotes at E18.5, mice are smaller than wild-type mice

limbs/digits/tail

short limbs ( J:154905 )

• while larger than in Ihh^tm1Amc homozygotes at E18.5, limbs are shorter than in wild-type mice