Phenotypes Associated with This Genotype

Genotype
MGI:4414674

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Gli2*)Flng}/Gt(ROSA)26Sor⁺; Ihh^tm1Amc/Ihh^tm1Amc; Tg(Col2a1-cre)3Amc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:154905 )

• mice die at birth

skeleton

skeleton phenotype ( J:154905 )

N • vascularization and bone formation in the diaphysis are normal

abnormal osteoblast differentiation ( J:154905 )

• similar to in Ihh^tm1Amc homozygotes, orthotopic osteoblast differentiation is impaired as determined by marker expression

abnormal long bone epiphyseal plate proliferative zone ( J:154905 )

• at E15.5 and E18.5, the proliferative zone is slightly larger than in Ihh^tm1Amc homozygotes but smaller than in wild-type mice

abnormal long bone hypertrophic chondrocyte zone ( J:154905 )

• vascularization of the hypertrophic zone is improved compared to in Ihh^tm1Amc homozygotes

disorganized long bone epiphyseal plate ( J:154905 )

• columnar organization of chondrocytes is partially restored compared to in Ihh^tm1Amc homozygotes but is still disorganized compared to in wild-type mice

abnormal perichondrium morphology ( J:154905 )

• at E18.5, mice fail to exhibit bone deposition in the perichondrium flanking the hypertrophic regions where the bone collar normally forms in the long bones of wild-type mice

cellular

abnormal osteoblast differentiation ( J:154905 )

• similar to in Ihh^tm1Amc homozygotes, orthotopic osteoblast differentiation is impaired as determined by marker expression