Mouse Genome Informatics
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    Tspan12tm1Wye/Tspan12tm1Wye
either: B6.129S5-Tspan12tm1Wye or FVB.129S5-Tspan12tm1Wye
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
N
• development of the intraneural vascular plexus is normal (J:154863)
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice
• between P5 and P12, outgrowth of nerve fiber layer vasculature is moderately delayed compared to in wild-type mice
• at P11, mice lack vertical sprouts and outer plexiform layer capillaries unlike in wild-type mice
• adult mice lack outer plexiform layer vasculature unlike in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice
• at P16, mice exhibit microaneurysms in the retina unlike in wild-type mice
• at 3 months, vessels are enlarged compared to in wild-type mice
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice
• adult mice exhibit focal hemorrhage in the retina unlike wild-type mice

vision/eye
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice
• between P5 and P12, outgrowth of nerve fiber layer vasculature is moderately delayed compared to in wild-type mice
• at P11, mice lack vertical sprouts and outer plexiform layer capillaries unlike in wild-type mice
• adult mice lack outer plexiform layer vasculature unlike in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice
• at P16, mice exhibit microaneurysms in the retina unlike in wild-type mice
• adult mice exhibit focal hemorrhage in the retina unlike wild-type mice
• regression of the hyaloid vessel is delayed compared to in wild-type mice
• between P5 and P12, outgrowth of nerve fiber layer vasculature is moderately delayed compared to in wild-type mice

hearing/vestibular/ear
• at 3 months, vessels are enlarged compared to in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Exudative Vitreoretinopathy 5; EVR5 613310 J:158585