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Phenotypes Associated with This Genotype
Genotype
MGI:4414647
Allelic
Composition
Tspan12tm1Wye/Tspan12tm1Wye
Genetic
Background
either: B6.129S5-Tspan12tm1Wye or FVB.129S5-Tspan12tm1Wye
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tspan12tm1Wye mutation (0 available); any Tspan12 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• development of the intraneural vascular plexus is normal (J:154863)
• development of the intraneural vascular plexus is normal (J:154863)
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice (J:154863)
• between P5 and P12, outgrowth of nerve fiber layer vasculature is moderately delayed compared to in wild-type mice (J:154863)
• at P11, mice lack vertical sprouts and outer plexiform layer capillaries unlike in wild-type mice (J:154863)
• adult mice lack outer plexiform layer vasculature unlike in wild-type mice (J:154863)
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice (J:154863)
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice (J:154863)
• between P5 and P12, outgrowth of nerve fiber layer vasculature is moderately delayed compared to in wild-type mice (J:154863)
• at P11, mice lack vertical sprouts and outer plexiform layer capillaries unlike in wild-type mice (J:154863)
• adult mice lack outer plexiform layer vasculature unlike in wild-type mice (J:154863)
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice (J:154863)
• at P16, mice exhibit microaneurysms in the retina unlike in wild-type mice (J:154863)
• at P16, mice exhibit microaneurysms in the retina unlike in wild-type mice (J:154863)
• at 3 months, vessels are enlarged compared to in wild-type mice (J:154863)
• at 3 months, vessels are enlarged compared to in wild-type mice (J:154863)
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice (J:154863)
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice (J:154863)
• adult mice exhibit focal hemorrhage in the retina unlike wild-type mice (J:154863)
• adult mice exhibit focal hemorrhage in the retina unlike wild-type mice (J:154863)

vision/eye
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice (J:154863)
• between P5 and P12, outgrowth of nerve fiber layer vasculature is moderately delayed compared to in wild-type mice (J:154863)
• at P11, mice lack vertical sprouts and outer plexiform layer capillaries unlike in wild-type mice (J:154863)
• adult mice lack outer plexiform layer vasculature unlike in wild-type mice (J:154863)
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice (J:154863)
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice (J:154863)
• between P5 and P12, outgrowth of nerve fiber layer vasculature is moderately delayed compared to in wild-type mice (J:154863)
• at P11, mice lack vertical sprouts and outer plexiform layer capillaries unlike in wild-type mice (J:154863)
• adult mice lack outer plexiform layer vasculature unlike in wild-type mice (J:154863)
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice (J:154863)
• at P16, mice exhibit microaneurysms in the retina unlike in wild-type mice (J:154863)
• at P16, mice exhibit microaneurysms in the retina unlike in wild-type mice (J:154863)
• adult mice exhibit focal hemorrhage in the retina unlike wild-type mice (J:154863)
• adult mice exhibit focal hemorrhage in the retina unlike wild-type mice (J:154863)
• regression of the hyaloid vessel is delayed compared to in wild-type mice (J:154863)
• regression of the hyaloid vessel is delayed compared to in wild-type mice (J:154863)
• between P5 and P12, outgrowth of nerve fiber layer vasculature is moderately delayed compared to in wild-type mice (J:154863)
• between P5 and P12, outgrowth of nerve fiber layer vasculature is moderately delayed compared to in wild-type mice (J:154863)

hearing/vestibular/ear
• at 3 months, vessels are enlarged compared to in wild-type mice (J:154863)
• at 3 months, vessels are enlarged compared to in wild-type mice (J:154863)

Mouse Models of Human Disease
OMIM ID Ref(s)
Exudative Vitreoretinopathy 5; EVR5 613310 J:158585


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory