Phenotypes for Gt(ROSA)26Sor Nkx6-2 MGI:4412378 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gt(ROSA)26Sor^{tm1.1(CAG-EGFP)Fsh}/Gt(ROSA)26Sor⁺ Nkx6-2^tm1Qiu/Nkx6-2^{tm1(cre/ERT2)Fsh}
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1.1(CAG-EGFP)Fsh} mutation (1 available); any Gt(ROSA)26Sor mutation (1098 available)
Nkx6-2^{tm1(cre/ERT2)Fsh} mutation (1 available); any Nkx6-2 mutation (16 available)
Nkx6-2^tm1Qiu mutation (0 available); any Nkx6-2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain interneuron morphology ( J:155164 )

• following tamoxifen treatment at E12.5, mice exhibit a small and partially penetrant loss of delayed non-fast spiking somatostatin/calretinin double positive cortical interneurons compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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