Phenotypes Associated with This Genotype

Genotype
MGI:4412287

• Allelic Composition: Gt(ROSA)26Sor^{tm7(CAG-mCherry,-EGFP/tetX)Dym}/Gt(ROSA)26Sor⁺; Tg(ACTFLPe)9205Dym/0; Tg(Atoh1-cre)1Bfri/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired balance ( J:154944 )

impaired coordination ( J:154944 )

abnormal gait ( J:154944 )

• aberrant foot print angles, irregular and reduced stride lengths

short stride length ( J:154944 )

nervous system

abnormal synaptic vesicle recycling ( J:154944 )

• parallel fibers accumulate unreleased synaptic vesicles unlike in wild-type cells

abnormal excitatory postsynaptic currents ( J:154944 )

• stimulation of parallel fibers fails to stimulate an excitatory postsynaptic current (EPSC) unlike in similarly treated wild-type mice

• however, extremely high stimulus intensities evoke an EPSC and stimulated parallel fibers propagate action potentials normally

hearing/vestibular/ear

abnormal ear physiology ( J:154944 )

• mice exhibit auditory defects