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Phenotypes Associated with This Genotype
Genotype
MGI:4412279
Allelic
Composition		 Prnptm1Lnq/Prnptm1Lnq
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Lnq mutation (0 available); any Prnp mutation (141 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to prion infection ( J:154937 )
• mice are resistant to laboratory mouse prion strain infection unlike wild-type mice
• however, mice are normally sensitive to hamster scrapie infection

nervous system
nervous system phenotype ( J:154937 )
N
• mice do not develop spontaneous neuropathology

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory