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Phenotypes Associated with This Genotype
Genotype
MGI:4412197
Allelic
Composition		 Lrp5tm1Kry/Lrp5tm1Kry
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat mutation (1 available); any Igs1 mutation (10 available)
Lrp5tm1Kry mutation (0 available); any Lrp5 mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, incomplete penetrance ( J:154020 )
• Background Sensitivity: mid-gestational lethality but some survival improvement

growth/size/body
embryonic growth retardation ( J:154020 )
• Background Sensitivity: growth retardation moderated

cardiovascular system
abnormal descending aorta morphology ( J:154020 )
• Background Sensitivity: disruption less severe
abnormal angiogenesis ( J:154020 )
• Background Sensitivity: less severely disrupted

embryo
embryonic growth retardation ( J:154020 )
• Background Sensitivity: growth retardation moderated

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory