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Phenotypes Associated with This Genotype
Genotype
MGI:4412195
Allelic
Composition		 Fzd4tm1Nat/Fzd4+
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (44 available)
Fzd4tm1Nat mutation (1 available); any Fzd4 mutation (33 available)
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat mutation (1 available); any Igs1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, incomplete penetrance ( J:154020 )
• Background Sensitivity: mid-gestational lethality but some survival to E18

growth/size/body
embryonic growth retardation ( J:154020 )
• Background Sensitivity: growth retardation moderated

cardiovascular system
abnormal descending aorta morphology ( J:154020 )
• Background Sensitivity: disruption less severe
abnormal angiogenesis ( J:154020 )
• Background Sensitivity: less severely disrupted

embryo
embryonic growth retardation ( J:154020 )
• Background Sensitivity: growth retardation moderated

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory