Mouse Genome Informatics
hm
    Fzd4tm1Nat/Fzd4tm1Nat
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• rod and cone signals are not transmitted effectively
• vascular development on the vitreal face of the retina is retarded
• retinal mural cells are thinner and lower in density than in controls
• electroretinogram a wave is relatively normal
• electroretinogram b wave is markedly reduced

behavior/neurological
• rod and cone signals are not transmitted effectively
• rod and cone signals are not transmitted effectively

nervous system
• progressive reduction in vascular density in the cerebellum
• misshapen capillaries in the cerebellum
• endothelial projections into the capillary lumen in the cerebellum
• leakage of IgG into the cerebellum
• frequent cerebellar hemorrhage but not in cerebral cortex
• cerebellar degeneration observed

cardiovascular system
• progressive reduction in vascular density in the cerebellum
• misshapen capillaries in the cerebellum
• endothelial projections into the capillary lumen in the cerebellum
• leakage of IgG into the cerebellum
• frequent cerebellar hemorrhage but not in cerebral cortex
• vascular development on the vitreal face of the retina is retarded
• retinal mural cells are thinner and lower in density than in controls

renal/urinary system
• at E18.5

Mouse Models of Human Disease
OMIM IDRef(s)
Exudative Vitreoretinopathy 1; EVR1 133780 J:158585