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Phenotypes Associated with This Genotype
Genotype
MGI:4412191
Allelic
Composition
Fzd4tm1Nat/Fzd4tm1Nat
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd4tm1Nat mutation (1 available); any Fzd4 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• rod and cone signals are not transmitted effectively (J:154020)
• rod and cone signals are not transmitted effectively (J:154020)
• vascular development on the vitreal face of the retina is retarded (J:154020)
• retinal mural cells are thinner and lower in density than in controls (J:154020)
• vascular development on the vitreal face of the retina is retarded (J:154020)
• retinal mural cells are thinner and lower in density than in controls (J:154020)
• electroretinogram a wave is relatively normal (J:154020)
• electroretinogram b wave is markedly reduced (J:154020)
• electroretinogram a wave is relatively normal (J:154020)
• electroretinogram b wave is markedly reduced (J:154020)

behavior/neurological
• rod and cone signals are not transmitted effectively (J:154020)
• rod and cone signals are not transmitted effectively (J:154020)
• rod and cone signals are not transmitted effectively (J:154020)
• rod and cone signals are not transmitted effectively (J:154020)

nervous system
• progressive reduction in vascular density in the cerebellum (J:154020)
• misshapen capillaries in the cerebellum (J:154020)
• endothelial projections into the capillary lumen in the cerebellum (J:154020)
• leakage of IgG into the cerebellum (J:154020)
• frequent cerebellar hemorrhage but not in cerebral cortex (J:154020)
• progressive reduction in vascular density in the cerebellum (J:154020)
• misshapen capillaries in the cerebellum (J:154020)
• endothelial projections into the capillary lumen in the cerebellum (J:154020)
• leakage of IgG into the cerebellum (J:154020)
• frequent cerebellar hemorrhage but not in cerebral cortex (J:154020)
• cerebellar degeneration observed (J:154020)
• cerebellar degeneration observed (J:154020)

cardiovascular system
• progressive reduction in vascular density in the cerebellum (J:154020)
• misshapen capillaries in the cerebellum (J:154020)
• endothelial projections into the capillary lumen in the cerebellum (J:154020)
• leakage of IgG into the cerebellum (J:154020)
• frequent cerebellar hemorrhage but not in cerebral cortex (J:154020)
• misshapen capillaries in the cerebellum (J:154020)
• progressive reduction in vascular density in the cerebellum (J:154020)
• endothelial projections into the capillary lumen in the cerebellum (J:154020)
• leakage of IgG into the cerebellum (J:154020)
• frequent cerebellar hemorrhage but not in cerebral cortex (J:154020)
• vascular development on the vitreal face of the retina is retarded (J:154020)
• retinal mural cells are thinner and lower in density than in controls (J:154020)
• vascular development on the vitreal face of the retina is retarded (J:154020)
• retinal mural cells are thinner and lower in density than in controls (J:154020)

renal/urinary system
• at E18.5 (J:170839)
• at E18.5 (J:170839)

Mouse Models of Human Disease
OMIM ID Ref(s)
Exudative Vitreoretinopathy 1; EVR1 133780 J:158585


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory