Analysis Tools
behavior/neurological
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• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2, 4 and 12 months compared with wild-type mice
• in a Morris water maze, mice exhibit exhibited decreased spatial learning half-way through the acquisition phase at 2 months compared with wild-type mice
• however, mice exhibit normal spatial learning by the end of the acquisition phase at 2, 4, and 12 months
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• on at rotarod at 12 months
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nervous system
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• at 4 months, mice exhibit tau plaques unlike wild-type mice
• tau deposits worsen with age
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