Phenotypes Associated with This Genotype

Genotype
MGI:4412005

• Allelic Composition: Cd14^tm1Frm/Cd14^tm1Frm
• Genetic Background: B6.129S4-Cd14^tm1Frm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

pulmonary edema ( J:96680 )

• less protein leakage into bronchoalveolar lavage fluid after lipopolysaccharide inhalation

immune system

abnormal cytokine level ( J:96680 )

• keratinocyte derived cytokine levels in lungs are unaffected by low doses of lipopolysaccharide

• macrophage inflammatory protein-2 levels in lungs are unaffected by low doses of lipopolysaccharide

abnormal interleukin level ( J:96680 )

• Il-6 levels in lungs are unaffected by low doses of lipopolysaccharide

abnormal tumor necrosis factor level ( J:96680 )

• TNF alpha levels in lungs are unaffected by low doses of lipopolysaccharide

skeleton

increased bone mineral content ( J:118467 )

• greater mineral content

increased bone mineral density ( J:118467 )

increased bone mass ( J:118467 )

• increased bone area of the tibia

decreased susceptibility to bone fracture ( J:118467 )

• bones resistant to fracture

homeostasis/metabolism

pulmonary edema ( J:96680 )

• less protein leakage into bronchoalveolar lavage fluid after lipopolysaccharide inhalation

abnormal cytokine level ( J:96680 )

• keratinocyte derived cytokine levels in lungs are unaffected by low doses of lipopolysaccharide

• macrophage inflammatory protein-2 levels in lungs are unaffected by low doses of lipopolysaccharide

abnormal interleukin level ( J:96680 )

• Il-6 levels in lungs are unaffected by low doses of lipopolysaccharide

abnormal tumor necrosis factor level ( J:96680 )

• TNF alpha levels in lungs are unaffected by low doses of lipopolysaccharide

adipose tissue

decreased total body fat amount ( J:118467 )

growth/size/body

increased lean body mass ( J:118467 )