Phenotypes Associated with This Genotype

Genotype
MGI:4410532

• Allelic Composition: Tg(CMV-RNAi:Pqbp1)1Hiok/0
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:154081 )

N • mice exhibit normal fear conditioning, motor function and learning, and spatial working memory

decreased anxiety-related response ( J:154081 )

• in an open field test, mice between 1.5 and 6 months of age spend more time in the center of the field compared with wild-type mice

• in a light-dark test, mice between 1.5 and 6 months of age spend more time in the light compartment compared with wild-type mice

• in an elevated plus maze, mice between 1.5 and 6 months of age spend more time in the open arms compared to wild-type mice

• mice exhibit impaired anxiety-related cognition compared with wild-type mice

• however, treatment with PBA (4-phenylbutyric acid) rescues impaired anxiety-related cognition

abnormal response to novel object ( J:154081 )

• in a novel object recognition test, the reduction in exploration of an object in a second trial is not as great as for wild-type mice

• mice exhibit impaired anxiety-related cognition compared with wild-type mice